{ "schema": "sim.tracer.citation_metadata.v1", "generated_utc": "2026-09-18T17:04:07.435589+00:00", "gate_run_id": "gate_20260917T182405Z", "source_package_md5": "34234cecc4f96c6b6785f3d6be928935", "resolver": { "entrypoint": "resolvers.resolve_accession -> pull_sources.pull_pubmed", "pull_sources_md5": "c7befc6c5c687b1255e5c62ce9a84e8b", "resolvers_md5": "dbc4e9f87bd6d5557c50e8c8636b1f68", "cache_root_repo_relative": "corpus/build_runtime/citation_cache", "refresh": false }, "interpretation": "Resolution proves the cited record EXISTS. It does not prove the record supports the claim it was cited for. Existence is machine-decidable; correspondence is a human judgment. Title, journal and year are rendered so a reader can judge correspondence. There is no verified state.", "abstract_policy": "Abstracts returned by the resolver are discarded at write time and are never stored in this file.", "unresolved_accepted": false, "counts": { "total": 17, "resolved": 17, "not_found": 0, "lookup_failed": 0 }, "coverage": { "measured_against_gate_run_id": "gate_20260917T182405Z", "measured_utc": "2026-09-18T17:04:07.435573+00:00", "distinct_pmids_cited_across_gate_runs": 17, "pmids_absent_from_package": [], "pmids_in_package": [ "23254930", "30381407", "31748742", "33235030", "33257576", "34219728", "37577847", "37792707", "37865133", "37874905", "37962000", "39486520", "39929578", "40792655", "41415576", "41962712", "42096692" ], "claims_carrying_citations": [ "admet_pk_hepatic", "central_target_engagement", "chronic_safety_margin", "cns_penetrance", "developability", "human_dose_projection", "in_vivo_pharmacology", "selectivity", "target_engagement", "target_rationale" ], "derivation": "Derived, not declared. The cited set is the union of per_rep_citation_audit over the run directories this gate's manifest names, upstream of the assembler; the in-package set is read from the assembler's evidence_package. Absent is cited minus package and is a refusal, never a silent zero. Live behavior on a gate other than the one this was built against is unproven.", "per_claim": [ { "claim_label": "chronic_safety_margin_sufficiency", "run_id": "sim_chronic_safety_margin_sufficiency_20260917T182406Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 10 }, { "claim_label": "target_rationale_sufficiency", "run_id": "sim_target_rationale_sufficiency_20260917T193932Z", "status": "resolved_low_conf", "reps": 5, "distinct_pmids_cited": 8 }, { "claim_label": "target_engagement_sufficiency", "run_id": "sim_target_engagement_sufficiency_20260917T210631Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 4 }, { "claim_label": "central_target_engagement_sufficiency", "run_id": "sim_central_target_engagement_sufficiency_20260917T222045Z", "status": "resolved_low_conf", "reps": 5, "distinct_pmids_cited": 4 }, { "claim_label": "in_vivo_pharmacology_sufficiency", "run_id": "sim_in_vivo_pharmacology_sufficiency_20260917T233543Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 8 }, { "claim_label": "selectivity_sufficiency", "run_id": "sim_selectivity_sufficiency_20260918T005050Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 4 }, { "claim_label": "cns_penetrance_sufficiency", "run_id": "sim_cns_penetrance_sufficiency_20260918T014742Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 7 }, { "claim_label": "admet_pk_hepatic_sufficiency", "run_id": "sim_admet_pk_hepatic_sufficiency_20260918T031515Z", "status": "resolved", "reps": 5, "distinct_pmids_cited": 5 }, { "claim_label": "developability_sufficiency", "run_id": "sim_developability_sufficiency_20260918T040520Z", "status": "resolved_low_conf", "reps": 5, "distinct_pmids_cited": 8 }, { "claim_label": "human_dose_projection_sufficiency", "run_id": "sim_human_dose_projection_sufficiency_20260918T052043Z", "status": "resolved_low_conf", "reps": 5, "distinct_pmids_cited": 6 } ], "retention_rule": "c1_reader.build_evidence_basis retains opening_*_cited_pmids and arbiter_verdict_notes for EVERY repetition, not only the low-confidence ones. sim_gate_assembler carries record.evidence_basis through unchanged and never filters it.", "note": "Coverage is bounded by what the repetitions reached for, not by what retention kept. Every identifier cited across this gate's runs appears in the package." }, "citations": [ { "pmid": "23254930", "cited_as": "PMID:23254930", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 2, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "A", "as_cited": "PMID:23254930" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:23254930" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:23254930" } ], "title": "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.", "journal": "Nature", "year": "2013", "doi": "10.1038/nature11729", "authors_all_count": 15, "author_first": "Heneka, Michael T" }, { "pmid": "30381407", "cited_as": "PMID:30381407", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 2, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "A", "as_cited": "PMID:30381407" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:30381407" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:30381407" } ], "title": "Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice.", "journal": "Science translational medicine", "year": "2018", "doi": "10.1126/scitranslmed.aah4066", "authors_all_count": 14, "author_first": "Gordon, Richard" }, { "pmid": "31748742", "cited_as": "PMID:31748742", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 2, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "A", "as_cited": "PMID:31748742" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:31748742" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:31748742" } ], "title": "NLRP3 inflammasome activation drives tau pathology.", "journal": "Nature", "year": "2019", "doi": "10.1038/s41586-019-1769-z", "authors_all_count": 22, "author_first": "Ising, Christina" }, { "pmid": "33235030", "cited_as": "PMID:33235030", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:33235030" } ], "title": "Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure.", "journal": "Journal of cardiovascular pharmacology", "year": "2020", "doi": "10.1097/FJC.0000000000000931", "authors_all_count": 19, "author_first": "Wohlford, George F" }, { "pmid": "33257576", "cited_as": "PMID:33257576", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "selectivity", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 2, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "developability", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 4, "position": "B", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 5, "position": "A", "as_cited": "PMID:33257576" }, { "claim_readout": "human_dose_projection", "rep_index": 5, "position": "B", "as_cited": "PMID:33257576" } ], "title": "The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "year": "2020", "doi": "10.1073/pnas.2009680117", "authors_all_count": 8, "author_first": "Lonnemann, Niklas" }, { "pmid": "34219728", "cited_as": "PMID:34219728", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:34219728" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "A", "as_cited": "PMID:34219728" } ], "title": "A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice.", "journal": "Journal of Alzheimer's disease : JAD", "year": "2021", "doi": "10.3233/JAD-210400", "authors_all_count": 9, "author_first": "Kuwar, Ram" }, { "pmid": "37577847", "cited_as": "PMID:37577847", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "chronic_safety_margin", "rep_index": 4, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "central_target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 1, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 2, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 4, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 5, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "A", "as_cited": "PMID:37577847" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "B", "as_cited": "PMID:37577847" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "A", "as_cited": "PMID:37577847" } ], "title": "Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZY-IL1 in Three Patients with Cryopyrin-Associated Periodic Syndromes.", "journal": "Clinical pharmacology in drug development", "year": "2024", "doi": "10.1002/cpdd.1318", "authors_all_count": 7, "author_first": "Hissaria, Pravin" }, { "pmid": "37792707", "cited_as": "PMID:37792707", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:37792707" } ], "title": "Comparative Evaluation of Particle Size Reduction, Salt Formation, and Amorphous Formulation on the Biopharmaceutical Performance of a Weak Base Drug Candidate.", "journal": "Molecular pharmaceutics", "year": "2023", "doi": "10.1021/acs.molpharmaceut.3c00727", "authors_all_count": 8, "author_first": "Zhang, Wei" }, { "pmid": "37865133", "cited_as": "PMID:37865133", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:37865133" } ], "title": "Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method.", "journal": "International journal of pharmaceutics", "year": "2023", "doi": "10.1016/j.ijpharm.2023.123536", "authors_all_count": 9, "author_first": "Al-Japairai, Khater" }, { "pmid": "37874905", "cited_as": "PMID:37874905", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 4, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 2, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 3, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "developability", "rep_index": 5, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "A", "as_cited": "PMID:37874905" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:37874905" }, { "claim_readout": "human_dose_projection", "rep_index": 5, "position": "A", "as_cited": "PMID:37874905" } ], "title": "Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.", "journal": "Journal of medicinal chemistry", "year": "2023", "doi": "10.1021/acs.jmedchem.3c01398", "authors_all_count": 11, "author_first": "Harrison, David" }, { "pmid": "37962000", "cited_as": "PMID:37962000", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:37962000" } ], "title": "A randomized, double-blind phase 1b study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of the NLRP3 inhibitor selnoflast in patients with moderate to severe active ulcerative colitis.", "journal": "Clinical and translational medicine", "year": "2023", "doi": "10.1002/ctm2.1471", "authors_all_count": 16, "author_first": "Klughammer, Barbara" }, { "pmid": "39486520", "cited_as": "PMID:39486520", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:39486520" } ], "title": "Vehicle effect on in-vitro and in-vivo performance of spray-dried dispersions.", "journal": "Journal of pharmaceutical sciences", "year": "2025", "doi": "10.1016/j.xphs.2024.10.043", "authors_all_count": 7, "author_first": "Nespi, Marika" }, { "pmid": "39929578", "cited_as": "PMID:39929578", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "admet_pk_hepatic", "rep_index": 5, "position": "A", "as_cited": "PMID:39929578" } ], "title": "Biological and therapeutic significance of targeting NLRP3 inflammasome in the brain and the current efforts to develop brain-penetrant inhibitors.", "journal": "Advances in pharmacology (San Diego, Calif.)", "year": "2025", "doi": "10.1016/bs.apha.2024.10.004", "authors_all_count": 6, "author_first": "Kaur, Baljit" }, { "pmid": "40792655", "cited_as": "PMID:40792655", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_rationale", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_rationale", "rep_index": 2, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_rationale", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_rationale", "rep_index": 4, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_rationale", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 1, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 2, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 3, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 4, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "central_target_engagement", "rep_index": 5, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "in_vivo_pharmacology", "rep_index": 4, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 1, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 2, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 3, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 4, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "cns_penetrance", "rep_index": 5, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 2, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 3, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "developability", "rep_index": 5, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "A", "as_cited": "PMID:40792655" }, { "claim_readout": "human_dose_projection", "rep_index": 1, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "human_dose_projection", "rep_index": 2, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "human_dose_projection", "rep_index": 3, "position": "B", "as_cited": "PMID:40792655" }, { "claim_readout": "human_dose_projection", "rep_index": 5, "position": "A", "as_cited": "PMID:40792655" } ], "title": "Anti-Neuroinflammatory and Anti-Inflammatory Effects of the NLRP3 Inhibitor NT-0796 in Subjects with Parkinson's Disease.", "journal": "Movement disorders : official journal of the Movement Disorder Society", "year": "2025", "doi": "10.1002/mds.30307", "authors_all_count": 12, "author_first": "Clarke, Nicholas" }, { "pmid": "41415576", "cited_as": "PMID:41415576", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "chronic_safety_margin", "rep_index": 5, "position": "A", "as_cited": "PMID:41415576" } ], "title": "Dapansutrile in multidisciplinary therapeutic applications: mechanisms and clinical perspectives.", "journal": "Frontiers in pharmacology", "year": "2025", "doi": "10.3389/fphar.2025.1731165", "authors_all_count": 3, "author_first": "Bai, Fuwei" }, { "pmid": "41962712", "cited_as": "PMID:41962712", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "developability", "rep_index": 1, "position": "A", "as_cited": "PMID:41962712" } ], "title": "NIM5 series brain-penetrant NLRP3 inflammasome inhibitors suppress neuroinflammation in EAE and Alzheimer's models.", "journal": "International journal of biological macromolecules", "year": "2026", "doi": "10.1016/j.ijbiomac.2026.151905", "authors_all_count": 5, "author_first": "Haseeb, Muhammad" }, { "pmid": "42096692", "cited_as": "PMID:42096692", "resolution_class": "resolved", "resolved": true, "reason": "", "cited_at": [ { "claim_readout": "developability", "rep_index": 4, "position": "A", "as_cited": "PMID:42096692" } ], "title": "OB-001 Enhances Osimertinib Brain Penetration: Preclinical Pharmacokinetics and Translational Rationale for EGFR-Mutant NSCLC with CNS Disease.", "journal": "Cancer research communications", "year": "2026", "doi": "10.1158/2767-9764.CRC-25-0553", "authors_all_count": 4, "author_first": "Mistry, Hitesh B" } ] }